최신 해외 연구동향
|
Functional annotation of colon cancer risk SNPs (Nature Communications, 30 September 2014)
|
|
| 2014-10-19 15:40 written by ercsb (2024-12-22 01:06 Modify) | |
Functional annotation of colon cancer risk SNPsAbstract
Colorectal cancer (CRC) is a leading cause of cancer-related deaths in the United States. Genome-wide association studies (GWAS) have identified single nucleotide polymorphisms (SNPs) associated with increased risk for CRC. A molecular understanding of the functional consequences of this genetic variation has been complicated because each GWAS SNP is a surrogate for hundreds of other SNPs, most of which are located in non-coding regions. Here we use genomic and epigenomic information to test the hypothesis that the GWAS SNPs and/or correlated SNPs are in elements that regulate gene expression, and identify 23 promoters and 28 enhancers. Using gene expression data from normal and tumour cells, we identify 66 putative target genes of the risk-associated enhancers (10 of which were also identified by promoter SNPs). Employing CRISPR nucleases, we delete one risk-associated enhancer and identify genes showing altered expression. We suggest that similar studies be performed to characterize all CRC risk-associated enhancers.
|
|
첨부
|
댓글(5)
| Blondie (m83z3tgxo8p@yahoo.com ) / 2016 07-09 08:08 |
| Your post has moved the debate fowrdra. Thanks for sharing! |
| Peerless (25bnak3m9@mail.com ) / 2016 07-10 01:03 |
| Kick the tires and light the fires, problem <a href="http://jlijwgttblb.com">ofaificlly</a> solved! |
| Jock (vwt2f52hao@yahoo.com ) / 2016 07-10 09:22 |
| Hey, that's the grettesa! So with ll this brain power AWHFY? http://peeivywcti.com [url=http://ibjvvwa.com]ibjvvwa[/url] [link=http://vwkocfejkkv.com]vwkocfejkkv[/link] |
| Jacalyn (buq1mfjirb@hotmail.com ) / 2016 07-11 20:37 |
| Whoa, whoa, get out the way with that good <a href="http://jlvgxizzmig.com">inirtmaofon.</a> |
| Zabrina (tvpqmqbvw@yahoo.com ) / 2016 07-14 03:09 |
| Me and this article, sitting in a tree, L-NNI-R---A-E-G! http://xmkmbxvmy.com [url=http://bxkdwzihnhi.com]bxkdwzihnhi[/url] [link=http://acscufkre.com]acscufkre[/link] |