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NCI-DREAM 약물 감수성 예측 컨소시엄
2015-03-24 13:13 written by ercsb (2023-12-11 21:52 Modify)
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NCI-DREAM 약물 감수성 예측 컨소시엄


NCI-DREAM Drug Sensitivity Prediction Challenge


조합 약물을 약물 내성을 줄이거나 약물 내성이 나타나는 것을 지연시켜주고 환자의 생존률을 높일 수 있으며 각 약물을 단독으로 사용했을 때보다 독성을 줄여주는 등의 시너지 효과를 낼 수 있다. 하지만 오히려 각 약물의 효과를 단독 사용 시 보다 감소시키는 경우도 있으며 따라서 효율적이 약물의 조합을 예측하는 것이 중요하다.

NCI는 주어진 14개 약물로 가능한 91개 약물 조합에 대해서 그 반응성을 예측하는 방법을 제시하는 DREAM consortium을 개최하였다. 참가 팀들에게는 각 약물에대한 용량 반응 곡선과 각 약물을 처리했을 때와 대조군에서의 유전자 발현 특징, 실험에 사용한 세포의 특징이 주어지며 이외에도 직접적인 실험결과를 제외한 반응 경로 정보등의 추가적인 정보도 사용할 수 있도록 하였다.


대회에 참가한 팀은 총 32 개 팀이였고, 각 팀은 91개 약물 조합에 대해 순위를 매겨 제출 했으며 이 결과를 직접 실험한 결과와 비교하여 각 팀의 순위가 정했졌다. 32개 팀 중 4개의 팀에서 제시한 방법의 효율이 뛰어났다. 가장 높은 점수를 받은 DIGRE 방법은 아래 그림과 같다.






이 외에 32개 팀이 제시한 모든 방법은 논문과 보조 자료를 통해 확인할 수 있다.



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